Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines

Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HA...

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Detalles Bibliográficos
Autores principales: Horwitz, Samantha M., Blue, Tamra C., Ambarian, Joseph A., Hoshino, Shotaro, Seyedsayamdost, Mohammad R., Davis, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984913/
https://www.ncbi.nlm.nih.gov/pubmed/35441142
http://dx.doi.org/10.1039/d1cb00255d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984913/
https://www.ncbi.nlm.nih.gov/pubmed/35441142
http://dx.doi.org/10.1039/d1cb00255d

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