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Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams

Spiro-heterocycles containing natural products and synthetic analogues have a broader biomedicinal application due to their rigid 3D conformation and structural implications. In this context, constructing spiro-isoxazoline systems have continued our interest in natural products and synthetic units t...

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Detalles Bibliográficos
Autores principales: Das, Prasanta, Carter, Cord, Shaheen, Gulrukh, Hamme, Ashton T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985116/
https://www.ncbi.nlm.nih.gov/pubmed/35424956
http://dx.doi.org/10.1039/d2ra01070d
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author Das, Prasanta
Carter, Cord
Shaheen, Gulrukh
Hamme, Ashton T.
author_facet Das, Prasanta
Carter, Cord
Shaheen, Gulrukh
Hamme, Ashton T.
author_sort Das, Prasanta
collection PubMed
description Spiro-heterocycles containing natural products and synthetic analogues have a broader biomedicinal application due to their rigid 3D conformation and structural implications. In this context, constructing spiro-isoxazoline systems have continued our interest in natural products and synthetic units to investigate their novel biological activities. Herein, a bromo-lactamization mediated neighboring group participation approach has been utilized on various isoxazole-amides to construct an array of spiro-isoxazoline-lactams. The easy synthesis with diverse functionalization in the periphery of a novel 3D framework could be interesting for biomedical investigation.
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spelling pubmed-89851162022-04-13 Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams Das, Prasanta Carter, Cord Shaheen, Gulrukh Hamme, Ashton T. RSC Adv Chemistry Spiro-heterocycles containing natural products and synthetic analogues have a broader biomedicinal application due to their rigid 3D conformation and structural implications. In this context, constructing spiro-isoxazoline systems have continued our interest in natural products and synthetic units to investigate their novel biological activities. Herein, a bromo-lactamization mediated neighboring group participation approach has been utilized on various isoxazole-amides to construct an array of spiro-isoxazoline-lactams. The easy synthesis with diverse functionalization in the periphery of a novel 3D framework could be interesting for biomedical investigation. The Royal Society of Chemistry 2022-03-28 /pmc/articles/PMC8985116/ /pubmed/35424956 http://dx.doi.org/10.1039/d2ra01070d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Das, Prasanta
Carter, Cord
Shaheen, Gulrukh
Hamme, Ashton T.
Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
title Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
title_full Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
title_fullStr Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
title_full_unstemmed Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
title_short Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
title_sort bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985116/
https://www.ncbi.nlm.nih.gov/pubmed/35424956
http://dx.doi.org/10.1039/d2ra01070d
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