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Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams
Spiro-heterocycles containing natural products and synthetic analogues have a broader biomedicinal application due to their rigid 3D conformation and structural implications. In this context, constructing spiro-isoxazoline systems have continued our interest in natural products and synthetic units t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985116/ https://www.ncbi.nlm.nih.gov/pubmed/35424956 http://dx.doi.org/10.1039/d2ra01070d |
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author | Das, Prasanta Carter, Cord Shaheen, Gulrukh Hamme, Ashton T. |
author_facet | Das, Prasanta Carter, Cord Shaheen, Gulrukh Hamme, Ashton T. |
author_sort | Das, Prasanta |
collection | PubMed |
description | Spiro-heterocycles containing natural products and synthetic analogues have a broader biomedicinal application due to their rigid 3D conformation and structural implications. In this context, constructing spiro-isoxazoline systems have continued our interest in natural products and synthetic units to investigate their novel biological activities. Herein, a bromo-lactamization mediated neighboring group participation approach has been utilized on various isoxazole-amides to construct an array of spiro-isoxazoline-lactams. The easy synthesis with diverse functionalization in the periphery of a novel 3D framework could be interesting for biomedical investigation. |
format | Online Article Text |
id | pubmed-8985116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-89851162022-04-13 Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams Das, Prasanta Carter, Cord Shaheen, Gulrukh Hamme, Ashton T. RSC Adv Chemistry Spiro-heterocycles containing natural products and synthetic analogues have a broader biomedicinal application due to their rigid 3D conformation and structural implications. In this context, constructing spiro-isoxazoline systems have continued our interest in natural products and synthetic units to investigate their novel biological activities. Herein, a bromo-lactamization mediated neighboring group participation approach has been utilized on various isoxazole-amides to construct an array of spiro-isoxazoline-lactams. The easy synthesis with diverse functionalization in the periphery of a novel 3D framework could be interesting for biomedical investigation. The Royal Society of Chemistry 2022-03-28 /pmc/articles/PMC8985116/ /pubmed/35424956 http://dx.doi.org/10.1039/d2ra01070d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Das, Prasanta Carter, Cord Shaheen, Gulrukh Hamme, Ashton T. Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams |
title | Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams |
title_full | Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams |
title_fullStr | Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams |
title_full_unstemmed | Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams |
title_short | Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams |
title_sort | bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985116/ https://www.ncbi.nlm.nih.gov/pubmed/35424956 http://dx.doi.org/10.1039/d2ra01070d |
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