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A novel screening strategy to identify histone methyltransferase inhibitors reveals a crosstalk between DOT1L and CARM1
Epigenetic regulation is a dynamic and reversible process that controls gene expression. Abnormal function results in human diseases such as cancer, thus the enzymes that establish epigenetic marks, such as histone methyltransferases (HMTs), are potentially therapeutic targets. Noteworthily, HMTs fo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985137/ https://www.ncbi.nlm.nih.gov/pubmed/35441144 http://dx.doi.org/10.1039/d1cb00095k |