A novel screening strategy to identify histone methyltransferase inhibitors reveals a crosstalk between DOT1L and CARM1

Epigenetic regulation is a dynamic and reversible process that controls gene expression. Abnormal function results in human diseases such as cancer, thus the enzymes that establish epigenetic marks, such as histone methyltransferases (HMTs), are potentially therapeutic targets. Noteworthily, HMTs fo...

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Detalles Bibliográficos
Autores principales: Si, Yang, Bon, Corentin, Barbachowska, Magdalena, Cadet-Daniel, Veronique, Jallet, Corinne, Soresinetti, Laura, Boullé, Mikaël, Duchateau, Magalie, Matondo, Mariette, Agou, Fabrice, Halby, Ludovic, Arimondo, Paola B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985137/
https://www.ncbi.nlm.nih.gov/pubmed/35441144
http://dx.doi.org/10.1039/d1cb00095k

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