Biochemical and structural characterization of Haemophilus influenzae nitroreductase in metabolizing nitroimidazoles

Nitroheterocycle antibiotics, particularly 5-nitroimidazoles, are frequently used for treating anaerobic infections. The antimicrobial activities of these drugs heavily rely on the in vivo bioactivation, mainly mediated by widely distributed bacterial nitroreductases (NTRs). However, the bioactivati...

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Detalles Bibliográficos
Autores principales: Liu, Dake, Wanniarachchi, Thisuri N., Jiang, Guangde, Seabra, Gustavo, Cao, Shugeng, Bruner, Steven D., Ding, Yousong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985140/
https://www.ncbi.nlm.nih.gov/pubmed/35441146
http://dx.doi.org/10.1039/d1cb00238d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985140/
https://www.ncbi.nlm.nih.gov/pubmed/35441146
http://dx.doi.org/10.1039/d1cb00238d

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