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Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation

Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved significantly over the last 4 years with the introduction of costimulation blockade based immunosuppression (IS) and genetically engineered (GE) pig donors. The longest survival of a cardiac xenograft in the heterotop...

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Autores principales: Singh, Avneesh K., Goerlich, Corbin E., Shah, Aakash M., Zhang, Tianshu, Tatarov, Ivan, Ayares, David, Horvath, Keith A., Mohiuddin, Muhammad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985160/
https://www.ncbi.nlm.nih.gov/pubmed/35401039
http://dx.doi.org/10.3389/ti.2022.10171
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author Singh, Avneesh K.
Goerlich, Corbin E.
Shah, Aakash M.
Zhang, Tianshu
Tatarov, Ivan
Ayares, David
Horvath, Keith A.
Mohiuddin, Muhammad M.
author_facet Singh, Avneesh K.
Goerlich, Corbin E.
Shah, Aakash M.
Zhang, Tianshu
Tatarov, Ivan
Ayares, David
Horvath, Keith A.
Mohiuddin, Muhammad M.
author_sort Singh, Avneesh K.
collection PubMed
description Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved significantly over the last 4 years with the introduction of costimulation blockade based immunosuppression (IS) and genetically engineered (GE) pig donors. The longest survival of a cardiac xenograft in the heterotopic (HHTx) position was almost 3 years and only rejected when IS was stopped. Recent reports of cardiac xenograft survival in a life-sustaining orthotopic (OHTx) position for 6 months is a significant step forward. Despite these achievements, there are still several barriers to the clinical success of xenotransplantation (XTx). This includes the possible transmission of porcine pathogens with pig donors and continued xenograft growth after XTx. Both these concerns, and issues with additional incompatibilities, have been addressed recently with the genetic modification of pigs. This review discusses the spectrum of issues related to cardiac xenotransplantation, recent progress in preclinical models, and its feasibility for clinical translation.
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spelling pubmed-89851602022-04-07 Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation Singh, Avneesh K. Goerlich, Corbin E. Shah, Aakash M. Zhang, Tianshu Tatarov, Ivan Ayares, David Horvath, Keith A. Mohiuddin, Muhammad M. Transpl Int Health Archive Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved significantly over the last 4 years with the introduction of costimulation blockade based immunosuppression (IS) and genetically engineered (GE) pig donors. The longest survival of a cardiac xenograft in the heterotopic (HHTx) position was almost 3 years and only rejected when IS was stopped. Recent reports of cardiac xenograft survival in a life-sustaining orthotopic (OHTx) position for 6 months is a significant step forward. Despite these achievements, there are still several barriers to the clinical success of xenotransplantation (XTx). This includes the possible transmission of porcine pathogens with pig donors and continued xenograft growth after XTx. Both these concerns, and issues with additional incompatibilities, have been addressed recently with the genetic modification of pigs. This review discusses the spectrum of issues related to cardiac xenotransplantation, recent progress in preclinical models, and its feasibility for clinical translation. Frontiers Media S.A. 2022-03-23 /pmc/articles/PMC8985160/ /pubmed/35401039 http://dx.doi.org/10.3389/ti.2022.10171 Text en Copyright © 2022 Singh, Goerlich, Shah, Zhang, Tatarov, Ayares, Horvath and Mohiuddin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Singh, Avneesh K.
Goerlich, Corbin E.
Shah, Aakash M.
Zhang, Tianshu
Tatarov, Ivan
Ayares, David
Horvath, Keith A.
Mohiuddin, Muhammad M.
Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
title Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
title_full Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
title_fullStr Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
title_full_unstemmed Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
title_short Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
title_sort cardiac xenotransplantation: progress in preclinical models and prospects for clinical translation
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985160/
https://www.ncbi.nlm.nih.gov/pubmed/35401039
http://dx.doi.org/10.3389/ti.2022.10171
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