Investigating treatment-effect modification by a continuous covariate in IPD meta-analysis: an approach using fractional polynomials

BACKGROUND: In clinical trials, there is considerable interest in investigating whether a treatment effect is similar in all patients, or that one or more prognostic variables indicate a differential response to treatment. To examine this, a continuous predictor is usually categorised into groups ac...

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Detalles Bibliográficos
Autores principales: Sauerbrei, Willi, Royston, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985287/
https://www.ncbi.nlm.nih.gov/pubmed/35382744
http://dx.doi.org/10.1186/s12874-022-01516-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985287/
https://www.ncbi.nlm.nih.gov/pubmed/35382744
http://dx.doi.org/10.1186/s12874-022-01516-w

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