Development of Hif1a Pharmacogenomic Mutation Models to Study Individual Variations in Drug Action for Tumor Hypoxia: An in Silico Approach

OBJECTIVE: Tumor hypoxia, a predominant feature of solid tumor produces drug resistance that significantly impacts a patient's clinical outcomes. Hypoxia-inducible factor 1-alpha (HIF1α) is the major mutation involved in establishing the microenvironment. As a consequence of its involvement in...

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Detalles Bibliográficos
Autores principales: Balasubramaniam, Vaisali, Namboori, P. K. Krishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985835/
https://www.ncbi.nlm.nih.gov/pubmed/35399804
http://dx.doi.org/10.4103/jpbs.jpbs_766_21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985835/
https://www.ncbi.nlm.nih.gov/pubmed/35399804
http://dx.doi.org/10.4103/jpbs.jpbs_766_21

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