VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells

Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by the accumulation of undifferentiated white blood cells (blasts) in the bone marrow. Valosin-containing protein (VCP) is an abundant molecular chaperone that extracts ubiquitylated substrates from protein complexes and cellul...

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Detalles Bibliográficos
Autores principales: Szczęśniak, Paweł P., Heidelberger, Jan B., Serve, Hubert, Beli, Petra, Wagner, Sebastian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986003/
https://www.ncbi.nlm.nih.gov/pubmed/35385564
http://dx.doi.org/10.1371/journal.pone.0266478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986003/
https://www.ncbi.nlm.nih.gov/pubmed/35385564
http://dx.doi.org/10.1371/journal.pone.0266478

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