Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway

In this investigation, a potentially novel signaling pathway in gentamicin-induced acute kidney injury—worsened by overexpression of proximal tubular enzyme, myo-inositol oxygenase (MIOX)—was elucidated. WT, MIOX-transgenic (MIOX-Tg), and MIOX-KO mice were used. Gentamicin was administered to induce...

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Detalles Bibliográficos
Autores principales: Sharma, Isha, Liao, Yingjun, Zheng, Xiaoping, Kanwar, Yashpal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986073/
https://www.ncbi.nlm.nih.gov/pubmed/35315361
http://dx.doi.org/10.1172/jci.insight.155487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986073/
https://www.ncbi.nlm.nih.gov/pubmed/35315361
http://dx.doi.org/10.1172/jci.insight.155487

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