Notch-mediated Ephrin signaling disrupts islet architecture and β cell function

Altered islet architecture is associated with β cell dysfunction and type 2 diabetes (T2D) progression, but molecular effectors of islet spatial organization remain mostly unknown. Although Notch signaling is known to regulate pancreatic development, we observed “reactivated” β cell Notch activity i...

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Detalles Bibliográficos
Autores principales: Bartolomé, Alberto, Suda, Nina, Yu, Junjie, Zhu, Changyu, Son, Jinsook, Ding, Hongxu, Califano, Andrea, Accili, Domenico, Pajvani, Utpal B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986078/
https://www.ncbi.nlm.nih.gov/pubmed/35167496
http://dx.doi.org/10.1172/jci.insight.157694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986078/
https://www.ncbi.nlm.nih.gov/pubmed/35167496
http://dx.doi.org/10.1172/jci.insight.157694

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