CMV-associated T cell and NK cell terminal differentiation does not affect immunogenicity of ChAdOx1 vaccination

Cytomegalovirus (CMV) is a globally ubiquitous pathogen with a seroprevalence of approximately 50% in the United Kingdom. CMV infection induces expansion of immunosenescent T cell and NK cell populations, with these cells demonstrating lower responsiveness to activation and reduced functionality upo...

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Detalles Bibliográficos
Autores principales: Sharpe, Hannah R., Provine, Nicholas M., Bowyer, Georgina S., Moreira Folegatti, Pedro, Belij-Rammerstorfer, Sandra, Flaxman, Amy, Makinson, Rebecca, Hill, Adrian V.S., Ewer, Katie J., Pollard, Andrew J., Klenerman, Paul, Gilbert, Sarah, Lambe, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986084/
https://www.ncbi.nlm.nih.gov/pubmed/35192547
http://dx.doi.org/10.1172/jci.insight.154187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986084/
https://www.ncbi.nlm.nih.gov/pubmed/35192547
http://dx.doi.org/10.1172/jci.insight.154187

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