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Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential

Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoieti...

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Detalles Bibliográficos
Autores principales: Nakao, Tetsushi, Bick, Alexander G., Taub, Margaret A., Zekavat, Seyedeh M., Uddin, Md M., Niroula, Abhishek, Carty, Cara L., Lane, John, Honigberg, Michael C., Weinstock, Joshua S., Pampana, Akhil, Gibson, Christopher J., Griffin, Gabriel K., Clarke, Shoa L., Bhattacharya, Romit, Assimes, Themistocles L., Emery, Leslie S., Stilp, Adrienne M., Wong, Quenna, Broome, Jai, Laurie, Cecelia A., Khan, Alyna T., Smith, Albert V., Blackwell, Thomas W., Codd, Veryan, Nelson, Christopher P., Yoneda, Zachary T., Peralta, Juan M., Bowden, Donald W., Irvin, Marguerite R., Boorgula, Meher, Zhao, Wei, Yanek, Lisa R., Wiggins, Kerri L., Hixson, James E., Gu, C. Charles, Peloso, Gina M., Roden, Dan M., Reupena, Muagututi’a S., Hwu, Chii-Min, DeMeo, Dawn L., North, Kari E., Kelly, Shannon, Musani, Solomon K., Bis, Joshua C., Lloyd-Jones, Donald M., Johnsen, Jill M., Preuss, Michael, Tracy, Russell P., Peyser, Patricia A., Qiao, Dandi, Desai, Pinkal, Curran, Joanne E., Freedman, Barry I., Tiwari, Hemant K., Chavan, Sameer, Smith, Jennifer A., Smith, Nicholas L., Kelly, Tanika N., Hidalgo, Bertha, Cupples, L. Adrienne, Weeks, Daniel E., Hawley, Nicola L., Minster, Ryan L., Deka, Ranjan, Naseri, Take T., de las Fuentes, Lisa, Raffield, Laura M., Morrison, Alanna C., Vries, Paul S., Ballantyne, Christie M., Kenny, Eimear E., Rich, Stephen S., Whitsel, Eric A., Cho, Michael H., Shoemaker, M. Benjamin, Pace, Betty S., Blangero, John, Palmer, Nicholette D., Mitchell, Braxton D., Shuldiner, Alan R., Barnes, Kathleen C., Redline, Susan, Kardia, Sharon L.R., Abecasis, Gonçalo R., Becker, Lewis C., Heckbert, Susan R., He, Jiang, Post, Wendy, Arnett, Donna K., Vasan, Ramachandran S., Darbar, Dawood, Weiss, Scott T., McGarvey, Stephen T., de Andrade, Mariza, Chen, Yii-Der Ida, Kaplan, Robert C., Meyers, Deborah A., Custer, Brian S., Correa, Adolfo, Psaty, Bruce M., Fornage, Myriam, Manson, JoAnn E., Boerwinkle, Eric, Konkle, Barbara A., Loos, Ruth J.F., Rotter, Jerome I., Silverman, Edwin K., Kooperberg, Charles, Danesh, John, Samani, Nilesh J., Jaiswal, Siddhartha, Libby, Peter, Ellinor, Patrick T., Pankratz, Nathan, Ebert, Benjamin L., Reiner, Alexander P., Mathias, Rasika A., Do, Ron, Natarajan, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986098/
https://www.ncbi.nlm.nih.gov/pubmed/35385311
http://dx.doi.org/10.1126/sciadv.abl6579