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Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis

INTRODUCTION: The mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood. OBJECTIVE: We evaluate the potential translational implications of intra-patient heterogeneity (IPH)...

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Detalles Bibliográficos
Autores principales: Kyrochristos, Ioannis D., Glantzounis, Georgios K., Goussia, Anna, Eliades, Alexia, Achilleos, Achilleas, Tsangaras, Kyriakos, Hadjidemetriou, Irene, Elpidorou, Marilena, Ioannides, Marios, Koumbaris, George, Mitsis, Michail, Patsalis, Philippos C., Roukos, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986149/
https://www.ncbi.nlm.nih.gov/pubmed/35402285
http://dx.doi.org/10.3389/fonc.2022.855463