Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells

Pyrrolizidine alkaloids (PAs) are a large group of highly toxic chemical compounds, which are found as cross-contaminants in numerous food products (e.g., honey), dietary supplements, herbal teas, and pharmaceutical herbal medicines. PA contaminations are responsible for serious hepatotoxicity and h...

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Detalles Bibliográficos
Autores principales: Abdelfatah, Sara, Naß, Janine, Knorz, Caroline, Klauck, Sabine M., Küpper, Jan-Heiner, Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986750/
https://www.ncbi.nlm.nih.gov/pubmed/33884520
http://dx.doi.org/10.1007/s10565-021-09599-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986750/
https://www.ncbi.nlm.nih.gov/pubmed/33884520
http://dx.doi.org/10.1007/s10565-021-09599-9

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