Enhancement of prime editing via xrRNA motif-joined pegRNA

The prime editors (PEs) have shown great promise for precise genome modification. However, their suboptimal efficiencies present a significant technical challenge. Here, by appending a viral exoribonuclease-resistant RNA motif (xrRNA) to the 3′-extended portion of pegRNAs for their increased resista...

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Detalles Bibliográficos
Autores principales: Zhang, Guiquan, Liu, Yao, Huang, Shisheng, Qu, Shiyuan, Cheng, Daolin, Yao, Yuan, Ji, Quanjiang, Wang, Xiaolong, Huang, Xingxu, Liu, Jianghuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986804/
https://www.ncbi.nlm.nih.gov/pubmed/35387980
http://dx.doi.org/10.1038/s41467-022-29507-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986804/
https://www.ncbi.nlm.nih.gov/pubmed/35387980
http://dx.doi.org/10.1038/s41467-022-29507-x

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