Design and optimization of metformin hydrophobic ion pairs for efficient encapsulation in polymeric drug carriers

Loading small molecular weight hydrophilic drugs into polymeric carriers is a challenging task. Metformin hydrochloride (MET) is a highly soluble oral antidiabetic drug of small size and high cationic charge. Hydrophobic ion pairing (HIP) is an approach for reversible modulation of solubility and hy...

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Detalles Bibliográficos
Autores principales: Abd-El Hafeez, Sara I., Eleraky, Nermin E., Hafez, Ehsan, Abouelmagd, Sara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986808/
https://www.ncbi.nlm.nih.gov/pubmed/35388027
http://dx.doi.org/10.1038/s41598-022-09384-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986808/
https://www.ncbi.nlm.nih.gov/pubmed/35388027
http://dx.doi.org/10.1038/s41598-022-09384-6

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