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Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury

Ferroptosis, a form of regulated cell death, plays an important role in acute kidney injury (AKI). Previous studies have shown that prolyl hydroxylase domain protein (PHD) inhibitors that activate HIF signaling provide strong protection against AKI, which is characterized by marked cell death. Howev...

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Autores principales: Li, Wenju, Xiang, Zhidan, Xing, Yuexian, Li, Shen, Shi, Shaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986825/
https://www.ncbi.nlm.nih.gov/pubmed/35387983
http://dx.doi.org/10.1038/s41419-022-04770-4
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author Li, Wenju
Xiang, Zhidan
Xing, Yuexian
Li, Shen
Shi, Shaolin
author_facet Li, Wenju
Xiang, Zhidan
Xing, Yuexian
Li, Shen
Shi, Shaolin
author_sort Li, Wenju
collection PubMed
description Ferroptosis, a form of regulated cell death, plays an important role in acute kidney injury (AKI). Previous studies have shown that prolyl hydroxylase domain protein (PHD) inhibitors that activate HIF signaling provide strong protection against AKI, which is characterized by marked cell death. However, the relationship between PHD inhibition/HIF signaling and ferroptosis in AKI has not been elucidated. Here, we review recent studies to explore the issue. First, we will review the literature concerning the functions of HIF in promoting mitophagy, suppressing mitochondrial respiration and modulating redox homeostasis. Second, we will describe the current understanding of ferroptosis and its role in AKI, particularly from the perspective of mitochondrial dysfunction. Finally, we will discuss the possibility that mitochondria link PHD inhibition/HIF signaling and ferroptosis in AKI. In conclusion, we propose that HIF may protect renal cells against ferroptosis in AKI by reducing mitochondrial oxidative stress and damage.
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spelling pubmed-89868252022-04-22 Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury Li, Wenju Xiang, Zhidan Xing, Yuexian Li, Shen Shi, Shaolin Cell Death Dis Review Article Ferroptosis, a form of regulated cell death, plays an important role in acute kidney injury (AKI). Previous studies have shown that prolyl hydroxylase domain protein (PHD) inhibitors that activate HIF signaling provide strong protection against AKI, which is characterized by marked cell death. However, the relationship between PHD inhibition/HIF signaling and ferroptosis in AKI has not been elucidated. Here, we review recent studies to explore the issue. First, we will review the literature concerning the functions of HIF in promoting mitophagy, suppressing mitochondrial respiration and modulating redox homeostasis. Second, we will describe the current understanding of ferroptosis and its role in AKI, particularly from the perspective of mitochondrial dysfunction. Finally, we will discuss the possibility that mitochondria link PHD inhibition/HIF signaling and ferroptosis in AKI. In conclusion, we propose that HIF may protect renal cells against ferroptosis in AKI by reducing mitochondrial oxidative stress and damage. Nature Publishing Group UK 2022-04-06 /pmc/articles/PMC8986825/ /pubmed/35387983 http://dx.doi.org/10.1038/s41419-022-04770-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Li, Wenju
Xiang, Zhidan
Xing, Yuexian
Li, Shen
Shi, Shaolin
Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury
title Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury
title_full Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury
title_fullStr Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury
title_full_unstemmed Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury
title_short Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury
title_sort mitochondria bridge hif signaling and ferroptosis blockage in acute kidney injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986825/
https://www.ncbi.nlm.nih.gov/pubmed/35387983
http://dx.doi.org/10.1038/s41419-022-04770-4
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