Identification of allosteric fingerprints of alpha-synuclein aggregates in matrix metalloprotease-1 and substrate-specific virtual screening with single molecule insights

Alpha-synuclein (aSyn) has implications in pathological protein aggregations in neurodegeneration. Matrix metalloproteases (MMPs) are broad-spectrum proteases and cleave aSyn, leading to aggregation. Previous reports showed that allosteric communications between the two domains of MMP1 on collagen f...

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Detalles Bibliográficos
Autores principales: Kamboj, Sumaer, Harms, Chase, Wright, Derek, Nash, Anthony, Kumar, Lokender, Klein-Seetharaman, Judith, Sarkar, Susanta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987064/
https://www.ncbi.nlm.nih.gov/pubmed/35388085
http://dx.doi.org/10.1038/s41598-022-09866-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987064/
https://www.ncbi.nlm.nih.gov/pubmed/35388085
http://dx.doi.org/10.1038/s41598-022-09866-7

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