Regioselective One-Pot Synthesis of Hydroxy-(S)-Equols Using Isoflavonoid Reductases and Monooxygenases and Evaluation of the Hydroxyequol Derivatives as Selective Estrogen Receptor Modulators and Antioxidants

Several regiospecific enantiomers of hydroxy-(S)-equol (HE) were enzymatically synthesized from daidzein and genistein using consecutive reduction (four daidzein-to-equol–converting reductases) and oxidation (4-hydroxyphenylacetate 3-monooxygenase, HpaBC). Despite the natural occurrence of several H...

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Detalles Bibliográficos
Autores principales: Song, Hanbit, Lee, Pyung-Gang, Kim, Junyeob, Kim, Joonwon, Lee, Sang-Hyuk, Kim, Hyun, Lee, Uk-Jae, Kim, Jin Young, Kim, Eun-Jung, Kim, Byung-Gee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987157/
https://www.ncbi.nlm.nih.gov/pubmed/35402392
http://dx.doi.org/10.3389/fbioe.2022.830712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987157/
https://www.ncbi.nlm.nih.gov/pubmed/35402392
http://dx.doi.org/10.3389/fbioe.2022.830712

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