Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia

Early T-cell development is precisely controlled by E proteins, that indistinguishably include HEB/TCF12 and E2A/TCF3 transcription factors, together with NOTCH1 and pre-T cell receptor (TCR) signalling. Importantly, perturbations of early T-cell regulatory networks are implicated in leukemogenesis....

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Detalles Bibliográficos
Autores principales: Veiga, Diogo F. T., Tremblay, Mathieu, Gerby, Bastien, Herblot, Sabine, Haman, André, Gendron, Patrick, Lemieux, Sébastien, Zúñiga-Pflücker, Juan Carlos, Hébert, Josée, Cohen, Joseph Paul, Hoang, Trang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987207/
https://www.ncbi.nlm.nih.gov/pubmed/35401501
http://dx.doi.org/10.3389/fimmu.2022.867443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987207/
https://www.ncbi.nlm.nih.gov/pubmed/35401501
http://dx.doi.org/10.3389/fimmu.2022.867443

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