DA-1241, a Novel GPR119 Agonist, Improves Hyperglycaemia by Inhibiting Hepatic Gluconeogenesis and Enhancing Insulin Secretion in Diabetic Mice

BACKGROUND: We investigated the antidiabetic effects of DA-1241, a novel G protein-coupled receptor (GPR) 119 agonist, in vitro and in vivo. METHODS: DA-1241 was administrated to high-fat diet (HFD)-fed C57BL/6J mice for 12 weeks after hyperglycaemia developed. Oral/intraperitoneal glucose tolerance...

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Detalles Bibliográficos
Autores principales: Kim, Youjin, Lee, Si Woo, Wang, Hyejin, Kim, Ryeong-Hyeon, Park, Hyun Ki, Lee, Hangkyu, Kang, Eun Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987681/
https://www.ncbi.nlm.nih.gov/pubmed/35052026
http://dx.doi.org/10.4093/dmj.2021.0056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987681/
https://www.ncbi.nlm.nih.gov/pubmed/35052026
http://dx.doi.org/10.4093/dmj.2021.0056

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