Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes

OBJECTIVE: MicroRNA 140 (miR-140) is a chondrocyte-specific endogenous gene regulator implicated in osteoarthritis (OA). As mechanical injury is a primary aetiological factor in OA, we investigated miR-140-dependent mechanosensitive gene regulation using a novel CRISPR-Cas9 methodology in primary hu...

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Detalles Bibliográficos
Autores principales: Chaudhry, N., Muhammad, H., Seidl, C., Downes, D., Young, D.A., Hao, Y., Zhu, L., Vincent, T.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987936/
https://www.ncbi.nlm.nih.gov/pubmed/35074547
http://dx.doi.org/10.1016/j.joca.2022.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987936/
https://www.ncbi.nlm.nih.gov/pubmed/35074547
http://dx.doi.org/10.1016/j.joca.2022.01.005

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