BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis

INTRODUCTION: In colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation. It remains unknown if inhibition of bromodomain and extra-terminal domain (BET) protein...

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Detalles Bibliográficos
Autores principales: Hoffner O’Connor, Michelle, Berglind, Ana, Kennedy Ng, Meaghan M., Keith, Benjamin P., Lynch, Zachary J., Schaner, Matthew R., Steinbach, Erin C., Herzog, Jeremy, Trad, Omar K., Jeck, William R., Arthur, Janelle C., Simon, Jeremy M., Sartor, R. Balfour, Furey, Terrence S., Sheikh, Shehzad Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988134/
https://www.ncbi.nlm.nih.gov/pubmed/35401533
http://dx.doi.org/10.3389/fimmu.2022.856966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988134/
https://www.ncbi.nlm.nih.gov/pubmed/35401533
http://dx.doi.org/10.3389/fimmu.2022.856966

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