HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

BACKGROUND: Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophages (TAMs) provide potent pro-tumoral support. However, TAMs...

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Detalles Bibliográficos
Autores principales: Hussain, Khiyam, Liu, Rena, Smith, Rosanna C. G., Müller, Kri T. J., Ghorbani, Mohammadmersad, Macari, Sofia, Cleary, Kirstie L. S., Oldham, Robert J., Foxall, Russell B., James, Sonya, Booth, Steven G., Murray, Tom, Dahal, Lekh N., Hargreaves, Chantal E., Kemp, Robert S., Longley, Jemma, Douglas, James, Markham, Hannah, Chee, Serena J., Stopforth, Richard J., Roghanian, Ali, Carter, Matthew J., Ottensmeier, Christian H., Frendéus, Bjorn, Cutress, Ramsey I., French, Ruth R., Glennie, Martin J., Strefford, Jonathan C., Thirdborough, Stephen M., Beers, Stephen A., Cragg, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988350/
https://www.ncbi.nlm.nih.gov/pubmed/35392965
http://dx.doi.org/10.1186/s13046-022-02294-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988350/
https://www.ncbi.nlm.nih.gov/pubmed/35392965
http://dx.doi.org/10.1186/s13046-022-02294-5

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