Production of Epoxyketone Peptide-Based Proteasome Inhibitors by Streptomyces sp. BRA-346: Regulation and Biosynthesis

Streptomyces sp. BRA-346 is an Actinobacteria isolated from the Brazilian endemic tunicate Euherdmania sp. We have reported that this strain produces epoxyketone peptides, as dihydroeponemycin (DHE) and structurally related analogs. This cocktail of epoxyketone peptides inhibits the proteasome chymo...

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Detalles Bibliográficos
Autores principales: Domingues Vieira, Bruna, Niero, Henrique, de Felício, Rafael, Giolo Alves, Luiz Fernando, Freitas Bazzano, Cristina, Sigrist, Renata, Costa Furtado, Luciana, Felix Persinoti, Gabriela, Veras Costa-Lotufo, Leticia, Barretto Barbosa Trivella, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988807/
https://www.ncbi.nlm.nih.gov/pubmed/35401454
http://dx.doi.org/10.3389/fmicb.2022.786008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988807/
https://www.ncbi.nlm.nih.gov/pubmed/35401454
http://dx.doi.org/10.3389/fmicb.2022.786008

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