Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya

BACKGROUND: Leading transmission-blocking vaccine candidates such as Plasmodium falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may render them ineffective or allele-specific. This study examines the level of genetic diversity, signature of selection and drivers of...

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Detalles Bibliográficos
Autores principales: Ochwedo, Kevin O., Onyango, Shirley A., Omondi, Collince J., Orondo, Pauline W., Ondeto, Benyl M., Lee, Ming-Chieh, Atieli, Harrysone E., Ogolla, Sidney O., Githeko, Andrew K., Otieno, Antony C. A., Mukabana, Wolfgang R., Yan, Guiyun, Zhong, Daibin, Kazura, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989228/
https://www.ncbi.nlm.nih.gov/pubmed/35390042
http://dx.doi.org/10.1371/journal.pone.0266394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989228/
https://www.ncbi.nlm.nih.gov/pubmed/35390042
http://dx.doi.org/10.1371/journal.pone.0266394

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