Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma

PURPOSE: Activation of STING (stimulator of interferon genes) can trigger a robust, innate antitumor immune response in immunologically “cold” tumors such as glioblastoma. PATIENTS AND METHODS: A small-molecule STING agonist, IACS-8779, was stereotactically administered using intraoperative navigati...

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Detalles Bibliográficos
Autores principales: Boudreau, C. Elizabeth, Najem, Hinda, Ott, Martina, Horbinski, Craig, Fang, Dexing, DeRay, Chase M., Levine, Jonathan M., Curran, Michael A., Heimberger, Amy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Clinical Trials: Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989401/
https://www.ncbi.nlm.nih.gov/pubmed/34433652
http://dx.doi.org/10.1158/1078-0432.CCR-21-1914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989401/
https://www.ncbi.nlm.nih.gov/pubmed/34433652
http://dx.doi.org/10.1158/1078-0432.CCR-21-1914

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