Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approach

BACKGROUND: The sarbecovirus subgenus of betacoronaviruses is widely distributed throughout bats and other mammals globally and includes human pathogens, SARS-CoV and SARS-CoV-2. The most studied sarbecoviruses use the host protein, ACE2, to infect cells. Curiously, the majority of sarbecoviruses id...

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Detalles Bibliográficos
Autores principales: Khaledian, Ehdieh, Ulusan, Sinem, Erickson, Jeffery, Fawcett, Stephen, Letko, Michael C., Broschat, Shira L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989474/
https://www.ncbi.nlm.nih.gov/pubmed/35405384
http://dx.doi.org/10.1016/j.ebiom.2022.103990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989474/
https://www.ncbi.nlm.nih.gov/pubmed/35405384
http://dx.doi.org/10.1016/j.ebiom.2022.103990

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