The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

Despite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remain an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation, chromatin occupancy, and stability, however the molecular basis rema...

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Detalles Bibliográficos
Autores principales: Wei, Yong, Redel, Cornelia, Ahlner, Alexandra, Lemak, Alexander, Johansson-Åkhe, Isak, Houliston, Scott, Kenney, Tristan M G, Tamachi, Aaliya, Morad, Vivian, Duan, Shili, Andrews, David W, Wallner, Björn, Sunnerhagen, Maria, Arrowsmith, Cheryl H, Penn, Linda Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989513/
https://www.ncbi.nlm.nih.gov/pubmed/35244724
http://dx.doi.org/10.1093/nar/gkac138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989513/
https://www.ncbi.nlm.nih.gov/pubmed/35244724
http://dx.doi.org/10.1093/nar/gkac138

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