The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity

Tet enzymes (Tet1/2/3) oxidize 5-methylcytosine to promote DNA demethylation and partner with chromatin modifiers to regulate gene expression. Tet1 is highly expressed in embryonic stem cells (ESCs), but its enzymatic and non-enzymatic roles in gene regulation are not dissected. We have generated Te...

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Detalles Bibliográficos
Autores principales: Chrysanthou, Stephanie, Tang, Qin, Lee, Joun, Taylor, Samuel J, Zhao, Yilin, Steidl, Ulrich, Zheng, Deyou, Dawlaty, Meelad M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989540/
https://www.ncbi.nlm.nih.gov/pubmed/35150568
http://dx.doi.org/10.1093/nar/gkac089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989540/
https://www.ncbi.nlm.nih.gov/pubmed/35150568
http://dx.doi.org/10.1093/nar/gkac089

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