Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases

Identifying rare variants that contribute to complex diseases is challenging because of the low statistical power in current tests comparing cases with controls. Here, we propose a novel and powerful rare variants association test based on the deviation of the observed mutation burden of a gene in c...

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Detalles Bibliográficos
Autores principales: Jiang, Lin, Jiang, Hui, Dai, Sheng, Chen, Ying, Song, Youqiang, Tang, Clara Sze-Man, Pang, Shirley Yin-Yu, Ho, Shu-Leong, Wang, Binbin, Garcia-Barcelo, Maria-Mercedes, Tam, Paul Kwong-Hang, Cherny, Stacey S, Li, Mulin Jun, Sham, Pak Chung, Li, Miaoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989543/
https://www.ncbi.nlm.nih.gov/pubmed/34931221
http://dx.doi.org/10.1093/nar/gkab1234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989543/
https://www.ncbi.nlm.nih.gov/pubmed/34931221
http://dx.doi.org/10.1093/nar/gkab1234

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