Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

Gα13 transduces signals from G-protein-coupled receptors. While Gα13 functions as a tumor suppressor in lymphomas, it is not known whether Gα13 is pro-tumorigenic or tumor suppressive in genetically engineered mouse (GEM) models of epithelial cancers. Here, we show that loss of Gα13 in the Kras/Tp53...

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Detalles Bibliográficos
Autores principales: Shields, Mario A., Spaulding, Christina, Metropulos, Anastasia E., Khalafalla, Mahmoud G., Pharm, Thao N.D., Munshi, Hidayatullah G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989626/
https://www.ncbi.nlm.nih.gov/pubmed/35235808
http://dx.doi.org/10.1016/j.celrep.2022.110441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989626/
https://www.ncbi.nlm.nih.gov/pubmed/35235808
http://dx.doi.org/10.1016/j.celrep.2022.110441

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