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Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

We examined antibody and memory B cell responses longitudinally for ∼9–10 months after primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody decay stabilized between 6 and 9 months, and antibody quality continued to improve for at least 9 months after 2-dose vaccination....

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Autores principales: Goel, Rishi R., Painter, Mark M., Lundgreen, Kendall A., Apostolidis, Sokratis A., Baxter, Amy E., Giles, Josephine R., Mathew, Divij, Pattekar, Ajinkya, Reynaldi, Arnold, Khoury, David S., Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Hicks, Amanda, Sharma, Harsh, Herring, Sarah, Korte, Scott, KC, Wumesh, Oldridge, Derek A., Erickson, Rachel I., Weirick, Madison E., McAllister, Christopher M., Awofolaju, Moses, Tanenbaum, Nicole, Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., McLaughlin, Maura, Williams, Justine C., Adamski, Sharon, Kuthuru, Oliva, Drapeau, Elizabeth M., Davenport, Miles P., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989683/
https://www.ncbi.nlm.nih.gov/pubmed/35523182
http://dx.doi.org/10.1016/j.cell.2022.04.009
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author Goel, Rishi R.
Painter, Mark M.
Lundgreen, Kendall A.
Apostolidis, Sokratis A.
Baxter, Amy E.
Giles, Josephine R.
Mathew, Divij
Pattekar, Ajinkya
Reynaldi, Arnold
Khoury, David S.
Gouma, Sigrid
Hicks, Philip
Dysinger, Sarah
Hicks, Amanda
Sharma, Harsh
Herring, Sarah
Korte, Scott
KC, Wumesh
Oldridge, Derek A.
Erickson, Rachel I.
Weirick, Madison E.
McAllister, Christopher M.
Awofolaju, Moses
Tanenbaum, Nicole
Dougherty, Jeanette
Long, Sherea
D’Andrea, Kurt
Hamilton, Jacob T.
McLaughlin, Maura
Williams, Justine C.
Adamski, Sharon
Kuthuru, Oliva
Drapeau, Elizabeth M.
Davenport, Miles P.
Hensley, Scott E.
Bates, Paul
Greenplate, Allison R.
Wherry, E. John
author_facet Goel, Rishi R.
Painter, Mark M.
Lundgreen, Kendall A.
Apostolidis, Sokratis A.
Baxter, Amy E.
Giles, Josephine R.
Mathew, Divij
Pattekar, Ajinkya
Reynaldi, Arnold
Khoury, David S.
Gouma, Sigrid
Hicks, Philip
Dysinger, Sarah
Hicks, Amanda
Sharma, Harsh
Herring, Sarah
Korte, Scott
KC, Wumesh
Oldridge, Derek A.
Erickson, Rachel I.
Weirick, Madison E.
McAllister, Christopher M.
Awofolaju, Moses
Tanenbaum, Nicole
Dougherty, Jeanette
Long, Sherea
D’Andrea, Kurt
Hamilton, Jacob T.
McLaughlin, Maura
Williams, Justine C.
Adamski, Sharon
Kuthuru, Oliva
Drapeau, Elizabeth M.
Davenport, Miles P.
Hensley, Scott E.
Bates, Paul
Greenplate, Allison R.
Wherry, E. John
author_sort Goel, Rishi R.
collection PubMed
description We examined antibody and memory B cell responses longitudinally for ∼9–10 months after primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody decay stabilized between 6 and 9 months, and antibody quality continued to improve for at least 9 months after 2-dose vaccination. Spike- and RBD-specific memory B cells remained durable over time, and 40%–50% of RBD-specific memory B cells simultaneously bound the Alpha, Beta, Delta, and Omicron variants. Omicron-binding memory B cells were efficiently reactivated by a 3rd dose of wild-type vaccine and correlated with the corresponding increase in neutralizing antibody titers. In contrast, pre-3rd dose antibody titers inversely correlated with the fold-change of antibody boosting, suggesting that high levels of circulating antibodies may limit the added protection afforded by repeat short interval boosting. These data provide insight into the quantity and quality of mRNA-vaccine-induced immunity over time through 3 or more antigen exposures.
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spelling pubmed-89896832022-04-11 Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine Goel, Rishi R. Painter, Mark M. Lundgreen, Kendall A. Apostolidis, Sokratis A. Baxter, Amy E. Giles, Josephine R. Mathew, Divij Pattekar, Ajinkya Reynaldi, Arnold Khoury, David S. Gouma, Sigrid Hicks, Philip Dysinger, Sarah Hicks, Amanda Sharma, Harsh Herring, Sarah Korte, Scott KC, Wumesh Oldridge, Derek A. Erickson, Rachel I. Weirick, Madison E. McAllister, Christopher M. Awofolaju, Moses Tanenbaum, Nicole Dougherty, Jeanette Long, Sherea D’Andrea, Kurt Hamilton, Jacob T. McLaughlin, Maura Williams, Justine C. Adamski, Sharon Kuthuru, Oliva Drapeau, Elizabeth M. Davenport, Miles P. Hensley, Scott E. Bates, Paul Greenplate, Allison R. Wherry, E. John Cell Article We examined antibody and memory B cell responses longitudinally for ∼9–10 months after primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody decay stabilized between 6 and 9 months, and antibody quality continued to improve for at least 9 months after 2-dose vaccination. Spike- and RBD-specific memory B cells remained durable over time, and 40%–50% of RBD-specific memory B cells simultaneously bound the Alpha, Beta, Delta, and Omicron variants. Omicron-binding memory B cells were efficiently reactivated by a 3rd dose of wild-type vaccine and correlated with the corresponding increase in neutralizing antibody titers. In contrast, pre-3rd dose antibody titers inversely correlated with the fold-change of antibody boosting, suggesting that high levels of circulating antibodies may limit the added protection afforded by repeat short interval boosting. These data provide insight into the quantity and quality of mRNA-vaccine-induced immunity over time through 3 or more antigen exposures. Elsevier Inc. 2022-05-26 2022-04-08 /pmc/articles/PMC8989683/ /pubmed/35523182 http://dx.doi.org/10.1016/j.cell.2022.04.009 Text en © 2022 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Goel, Rishi R.
Painter, Mark M.
Lundgreen, Kendall A.
Apostolidis, Sokratis A.
Baxter, Amy E.
Giles, Josephine R.
Mathew, Divij
Pattekar, Ajinkya
Reynaldi, Arnold
Khoury, David S.
Gouma, Sigrid
Hicks, Philip
Dysinger, Sarah
Hicks, Amanda
Sharma, Harsh
Herring, Sarah
Korte, Scott
KC, Wumesh
Oldridge, Derek A.
Erickson, Rachel I.
Weirick, Madison E.
McAllister, Christopher M.
Awofolaju, Moses
Tanenbaum, Nicole
Dougherty, Jeanette
Long, Sherea
D’Andrea, Kurt
Hamilton, Jacob T.
McLaughlin, Maura
Williams, Justine C.
Adamski, Sharon
Kuthuru, Oliva
Drapeau, Elizabeth M.
Davenport, Miles P.
Hensley, Scott E.
Bates, Paul
Greenplate, Allison R.
Wherry, E. John
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
title Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
title_full Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
title_fullStr Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
title_full_unstemmed Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
title_short Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
title_sort efficient recall of omicron-reactive b cell memory after a third dose of sars-cov-2 mrna vaccine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989683/
https://www.ncbi.nlm.nih.gov/pubmed/35523182
http://dx.doi.org/10.1016/j.cell.2022.04.009
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