SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

The kinase Csk is the primary negative regulator of the Src-family kinases (SFKs, e.g., Lck, Fyn, Lyn, Hck, Fgr, Blk, Yes), phosphorylating a tyrosine on the SFK C-terminal tail that mediates autoinhibition. Csk also binds phosphatases, including PTPN12 (PTP-PEST) and immune-cell PTPN22 (LYP/Pep), w...

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Detalles Bibliográficos
Autores principales: Brian, Ben F., Sjaastad, Frances V., Freedman, Tanya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989918/
https://www.ncbi.nlm.nih.gov/pubmed/35393453
http://dx.doi.org/10.1038/s41598-022-09589-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989918/
https://www.ncbi.nlm.nih.gov/pubmed/35393453
http://dx.doi.org/10.1038/s41598-022-09589-9

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