MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment

Targeted agents have emerged as promising molecules for cancer treatment, but most of them fail to achieve complete tumor regression or attain durable remissions due to tumor adaptations. We used dynamic BH3 profiling to identify targeted agents effectiveness and anti-apoptotic adaptations upon targ...

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Detalles Bibliográficos
Autores principales: Alcon, Clara, Martín, Fernando, Prada, Estela, Mora, Jaume, Soriano, Aroa, Guillén, Gabriela, Gallego, Soledad, Roma, Josep, Samitier, Josep, Villanueva, Alberto, Montero, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989976/
https://www.ncbi.nlm.nih.gov/pubmed/35393436
http://dx.doi.org/10.1038/s41420-022-00959-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989976/
https://www.ncbi.nlm.nih.gov/pubmed/35393436
http://dx.doi.org/10.1038/s41420-022-00959-w

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