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Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells
Myotonic dystrophy type 1 (DM1) is a dominantly inherited disorder due to a toxic gain of function of RNA transcripts containing expanded CUG repeats (CUG(exp)). Patients with DM1 present with multisystemic symptoms, such as muscle wasting, cognitive impairment, cataract, frontal baldness, and endoc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990169/ https://www.ncbi.nlm.nih.gov/pubmed/35401669 http://dx.doi.org/10.3389/fgene.2022.865811 |