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Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells

Myotonic dystrophy type 1 (DM1) is a dominantly inherited disorder due to a toxic gain of function of RNA transcripts containing expanded CUG repeats (CUG(exp)). Patients with DM1 present with multisystemic symptoms, such as muscle wasting, cognitive impairment, cataract, frontal baldness, and endoc...

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Detalles Bibliográficos
Autores principales:	Hasuike, Yuhei, Mochizuki, Hideki, Nakamori, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990169/ https://www.ncbi.nlm.nih.gov/pubmed/35401669 http://dx.doi.org/10.3389/fgene.2022.865811

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