Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates tumor progression and bone destruction. We previously showed that osteocytes activate Notch, increase Notch3 expression, and stimulate proliferation in MM cells. We show here that Notch3 inhibition in MM cells...

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Detalles Bibliográficos
Autores principales: Sabol, Hayley M., Amorim, Tânia, Ashby, Cody, Halladay, David, Anderson, Judith, Cregor, Meloney, Sweet, Megan, Nookaew, Intawat, Kurihara, Noriyoshi, Roodman, G. David, Bellido, Teresita, Delgado-Calle, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990177/
https://www.ncbi.nlm.nih.gov/pubmed/35390742
http://dx.doi.org/10.1016/j.neo.2022.100785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990177/
https://www.ncbi.nlm.nih.gov/pubmed/35390742
http://dx.doi.org/10.1016/j.neo.2022.100785

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