Protein kinase Cα activation switches YAP1 from TEAD‐mediated signaling to p73‐mediated signaling

Yes‐associated protein 1 (YAP1) interacts with TEAD transcription factor in the nucleus and upregulates TEAD‐target genes. YAP1 is phosphorylated by large tumor suppressor (LATS) kinases, the core kinases of the Hippo pathway, at 5 serine residues and is sequestered and degraded in the cytoplasm. In...

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Detalles Bibliográficos
Autores principales: Sinclear, Caleb Kwame, Maruyama, Junichi, Nagashima, Shunta, Arimoto‐Matsuzaki, Kyoko, Kuleape, Joshua Agbemefa, Iwasa, Hiroaki, Nishina, Hiroshi, Hata, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990296/
https://www.ncbi.nlm.nih.gov/pubmed/35102644
http://dx.doi.org/10.1111/cas.15285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990296/
https://www.ncbi.nlm.nih.gov/pubmed/35102644
http://dx.doi.org/10.1111/cas.15285

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