Cargando…
Protein kinase Cα activation switches YAP1 from TEAD‐mediated signaling to p73‐mediated signaling
Yes‐associated protein 1 (YAP1) interacts with TEAD transcription factor in the nucleus and upregulates TEAD‐target genes. YAP1 is phosphorylated by large tumor suppressor (LATS) kinases, the core kinases of the Hippo pathway, at 5 serine residues and is sequestered and degraded in the cytoplasm. In...
Autores principales: | Sinclear, Caleb Kwame, Maruyama, Junichi, Nagashima, Shunta, Arimoto‐Matsuzaki, Kyoko, Kuleape, Joshua Agbemefa, Iwasa, Hiroaki, Nishina, Hiroshi, Hata, Yutaka |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990296/ https://www.ncbi.nlm.nih.gov/pubmed/35102644 http://dx.doi.org/10.1111/cas.15285 |
Ejemplares similares
-
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells
por: Nagashima, Shunta, et al.
Publicado: (2021) -
Gatekeepers of pancreas: TEAD and YAP
por: Rodríguez-Seguí, Santiago A., et al.
Publicado: (2015) -
FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling
por: Knyazeva, Anastasia, et al.
Publicado: (2020) -
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration
por: Guillermin, Oriane, et al.
Publicado: (2021) -
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
por: Fan, Mengyang, et al.
Publicado: (2022)