An Optogenetic Arrhythmia Model—Insertion of Several Catecholaminergic Polymorphic Ventricular Tachycardia Mutations Into Caenorhabditis elegans UNC-68 Disturbs Calstabin-Mediated Stabilization of the Ryanodine Receptor Homolog

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disturbance of the heart rhythm (arrhythmia) that is induced by stress or that occurs during exercise. Most mutations that have been linked to CPVT are found in two genes, i.e., ryanodine receptor 2 (RyR2) and calsequestrin...

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Detalles Bibliográficos
Autores principales: Engel, Marcial Alexander, Wörmann, Yves René, Kaestner, Hanna, Schüler, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990320/
https://www.ncbi.nlm.nih.gov/pubmed/35399287
http://dx.doi.org/10.3389/fphys.2022.691829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990320/
https://www.ncbi.nlm.nih.gov/pubmed/35399287
http://dx.doi.org/10.3389/fphys.2022.691829

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