Cargando…

Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction

Due to increased drug and radiation tolerance, there is an urgent need to develop novel anticancer agents. In our previous study, we performed a series of structural modifications of ursolic acid (UA), a natural product of pentacyclic triterpenes, and found UA232, a derivative with stronger anti-tum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gou, Wenfeng, Luo, Na, Yu, Bing, Wu, Hongying, Wu, Shaohua, Tian, Chen, Guo, Jianghong, Ning, Hongxin, Bi, Changfen, Wei, Huiqiang, Hou, Wenbin, Li, Yiliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990475/ https://www.ncbi.nlm.nih.gov/pubmed/35414766 http://dx.doi.org/10.7150/ijbs.67166

Ejemplares similares

Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress
por: Gou, Wenfeng, et al.
Publicado: (2020)

Phosphate group functionalized magnetic metal–organic framework nanocomposite for highly efficient removal of U(VI) from aqueous solution
por: Bi, Changfen, et al.
Publicado: (2021)

Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease
por: Kurzawa-Akanbi, Marzena, et al.
Publicado: (2012)

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
por: Garrity, Abigail G, et al.
Publicado: (2016)

The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes
por: Lu, Meng, et al.
Publicado: (2020)

The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2
por: Bonet-Ponce, Luis, et al.
Publicado: (2022)

Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159
por: Park, Soon-Nang, et al.
Publicado: (2015)

ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum
por: Reggiori, Fulvio, et al.
Publicado: (2022)

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
por: Radulovic, Maja, et al.
Publicado: (2022)

Molecular mechanisms of isoflavone puerarin against cardiovascular diseases: What we know and where we go
por: Qin, Weida, et al.
Publicado: (2022)

CYTOLOGICAL STUDIES ON TWO FUNCTIONAL HEPATOMAS : Interrelations of Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes
por: Essner, Edward, et al.
Publicado: (1962)

Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress- and Ca(2+) Imbalance-Mediated Endoplasmic Reticulum Stress
por: Cui, Jiahui, et al.
Publicado: (2019)

AN ELECTRON MICROSCOPE STUDY OF MATURE AND DIFFERENTIATING PANETH CELLS IN THE RAT, ESPECIALLY OF THEIR ENDOPLASMIC RETICULUM AND LYSOSOMES
por: Behnke, O., et al.
Publicado: (1964)

Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts
por: Nakashima, Akitoshi, et al.
Publicado: (2019)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

Endoplasmic reticulum, Golgi, and lysosomes are disorganized in lung fibroblasts from chronic obstructive pulmonary disease patients
por: Weidner, Julie, et al.
Publicado: (2018)

Inositol Triphosphate Signaling Triggers Lysosome Biogenesis Via Calcium Release from Endoplasmic Reticulum Stores
por: Malek, Mouhannad, et al.
Publicado: (2022)

Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer
por: Chen, Shaohua, et al.
Publicado: (2015)

Construction of the endoplasmic reticulum
Publicado: (1989)

Ursolic Acid Impairs Cellular Lipid Homeostasis and Lysosomal Membrane Integrity in Breast Carcinoma Cells
por: Fogde, Ditte L., et al.
Publicado: (2022)

Effects of homocysteine-induced endoplasmic reticulum protein on endoplasmic reticulum stress, autophagy, and neuronal apoptosis following intracerebral hemorrhage
por: Wu, Hui, et al.
Publicado: (2020)

Mistargeting of the Lectin ERGIC-53 to the Endoplasmic Reticulum of HeLa Cells Impairs the Secretion of a Lysosomal Enzyme
por: Vollenweider, Florence, et al.
Publicado: (1998)

Endoplasmic reticulum and lysosomal Ca(2+) stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts
por: Kilpatrick, Bethan S., et al.
Publicado: (2016)

Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
por: Kawaguchi, Kosuke, et al.
Publicado: (2016)

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit
por: Roca, Francisco J., et al.
Publicado: (2019)

Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia
por: Han, Yu, et al.
Publicado: (2021)

An Improved Synthesis of the Triethylene Glycol-Substituted 4-(N-Methyl-N-Boc-Amino)Styrylpyridine
por: Jia, Jianhua, et al.
Publicado: (2020)

Correction to An Improved Synthesis of the Triethylene Glycol-Substituted 4-(N-Methyl-N-Boc-Amino)Styrylpyridine
por: Jia, Jianhua, et al.
Publicado: (2020)

Endoplasmic reticulum stress response in yeast and humans
por: Wu, Haoxi, et al.
Publicado: (2014)

Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades
por: Chen, Shaohua, et al.
Publicado: (2014)

The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol
por: Poirier, Steve, et al.
Publicado: (2013)

Inositol triphosphate–triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3
por: Malek, Mouhannad, et al.
Publicado: (2022)

Endoplasmic Reticulum Stress in Osteoarthritis: A Novel Perspective on the Pathogenesis and Treatment
por: Wen, Zeqin, et al.
Publicado: (2023)

Comprehensive analysis of the endoplasmic reticulum stress-related long non-coding RNA in bladder cancer
por: Wu, Zhenyu, et al.
Publicado: (2022)

A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum
por: Wu, Lichang, et al.
Publicado: (2016)

Endoplasmic Reticulum Stress and Cancer
por: Yadav, Raj Kumar, et al.
Publicado: (2014)

Regulation of endoplasmic reticulum functions
por: Namba, Takushi
Publicado: (2015)

Endoplasmic reticulum stress and apoptosis
por: Faitova, Jitka, et al.
Publicado: (2006)

Autophagic degradation of the endoplasmic reticulum
por: NAKATOGAWA, Hitoshi
Publicado: (2020)

Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum
por: Mitsuda, Satoshi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_op9eoembvtuas469sttcpge6kj