PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production

PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate the biology of this central nervous system (CNS)-resident myeloid population, but the indirect or off-target effects of this agent remain largely unexplored. In a murine model of severe neuroinflammation induce...

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Detalles Bibliográficos
Autores principales: Spiteri, Alanna G., Ni, Duan, Ling, Zheng Lung, Macia, Laurence, Campbell, Iain L., Hofer, Markus J., King, Nicholas J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990748/
https://www.ncbi.nlm.nih.gov/pubmed/35401512
http://dx.doi.org/10.3389/fimmu.2022.851556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990748/
https://www.ncbi.nlm.nih.gov/pubmed/35401512
http://dx.doi.org/10.3389/fimmu.2022.851556

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