Cargando…

PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production

PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate the biology of this central nervous system (CNS)-resident myeloid population, but the indirect or off-target effects of this agent remain largely unexplored. In a murine model of severe neuroinflammation induce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spiteri, Alanna G., Ni, Duan, Ling, Zheng Lung, Macia, Laurence, Campbell, Iain L., Hofer, Markus J., King, Nicholas J. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990748/ https://www.ncbi.nlm.nih.gov/pubmed/35401512 http://dx.doi.org/10.3389/fimmu.2022.851556

Ejemplares similares

Putting PLX5622 into perspective: microglia in central nervous system viral infection
por: Spiteri, Alanna G., et al.
Publicado: (2022)

Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
por: Mein, Nils, et al.
Publicado: (2023)

Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection
por: Spiteri, Alanna G., et al.
Publicado: (2023)

Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622
por: Lei, Fengyang, et al.
Publicado: (2021)

Significant Sex Differences in the Efficacy of the CSF1R Inhibitor-PLX5622 on Rat Brain Microglia Elimination
por: Sharon, Aviv, et al.
Publicado: (2022)

Terminal field volume of the glossopharyngeal nerve in adult rats reverts to prepruning size following microglia depletion with PLX5622
por: Riquier, Andrew J., et al.
Publicado: (2022)

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice
por: Ali, Seemaab, et al.
Publicado: (2020)

A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes
por: Bhatia, Tarun N., et al.
Publicado: (2023)

Clodronate is not protective in lethal viral encephalitis despite substantially reducing inflammatory monocyte infiltration in the CNS
por: Spiteri, Alanna G., et al.
Publicado: (2023)

CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice
por: Bosch, Angela J. T., et al.
Publicado: (2023)

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
por: Spiteri, Alanna G., et al.
Publicado: (2021)

Genome Sequence of Streptomyces olindensis DAUFPE 5622, Producer of the Antitumoral Anthracycline Cosmomycin D
por: Rojas, Juan D., et al.
Publicado: (2014)

Pre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality
por: Kumar, Vidya P., et al.
Publicado: (2022)

Impact of Dietary Fiber on West Nile Virus Infection
por: Ni, Duan, et al.
Publicado: (2022)

Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
por: Okojie, Akhabue K., et al.
Publicado: (2023)

Vitamin C sensitizes BRAF(V600E) thyroid cancer to PLX4032 via inhibiting the feedback activation of MAPK/ERK signal by PLX4032
por: Su, Xi, et al.
Publicado: (2021)

Plx1 is required for chromosomal DNA replication under stressful conditions
por: Trenz, Kristina, et al.
Publicado: (2008)

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
por: Choi, Jaehyuk, et al.
Publicado: (2014)

Bacillus anthracis’ lethal toxin induces broad transcriptional responses in human peripheral monocytes
por: Chauncey, Kassidy M, et al.
Publicado: (2012)

Immovable Object Meets Unstoppable Force? Dialogue Between Resident and Peripheral Myeloid Cells in the Inflamed Brain
por: Spiteri, Alanna G., et al.
Publicado: (2020)

High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease
por: Spiteri, Alanna G., et al.
Publicado: (2021)

Comparative Review of Microglia and Monocytes in CNS Phagocytosis
por: Andoh, Megumi, et al.
Publicado: (2021)

ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition
por: Maruyama, Takeshi, et al.
Publicado: (2020)

PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism
por: Garbarino, Ombretta, et al.
Publicado: (2023)

CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation
por: Kim, Jin Hyoung, et al.
Publicado: (2015)

Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain
por: Ni, Rong-Jun, et al.
Publicado: (2023)

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration
por: Peralta Ramos, Javier María, et al.
Publicado: (2019)

The Role of Peripheral CNS-Directed Antibodies in Promoting Inflammatory CNS Demyelination
por: Kinzel, Silke, et al.
Publicado: (2017)

Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression
por: Michaelis, Martin, et al.
Publicado: (2014)

PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells
por: George, Andrea L., et al.
Publicado: (2015)

Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394
por: Siljamäki, Elina, et al.
Publicado: (2023)

Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection
por: Jung, So Ri, et al.
Publicado: (2020)

Chemokine Actions in the CNS: Insights from Transgenic Mice
por: Müller, Marcus, et al.
Publicado: (2008)

CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia
por: Zimmermann, Julian, et al.
Publicado: (2013)

Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
por: Wong, Oi Kwan, et al.
Publicado: (2005)

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel
por: Piawah, Sorbarikor, et al.
Publicado: (2019)

Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO
por: Gelfand, Jeffrey M., et al.
Publicado: (2014)

Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS
por: Papavasiliou, F. Nina, et al.
Publicado: (2016)

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity
por: Rua, Rejane, et al.
Publicado: (2019)

IDO and Kynurenine Metabolites in Peripheral and CNS Disorders
por: Huang, Yi-Shu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q2osdf38vtphjlc8v4aoemnmve