Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and progressive neurodegeneration. Pathogenic variants in the WFS1 gene are the main causes of Wolfram syndrome. WFS1 encodes a transmembrane protein...

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Detalles Bibliográficos
Autores principales: Morikawa, Shuntaro, Blacher, Lindsey, Onwumere, Chinyere, Urano, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990750/
https://www.ncbi.nlm.nih.gov/pubmed/35399956
http://dx.doi.org/10.3389/fendo.2022.849204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990750/
https://www.ncbi.nlm.nih.gov/pubmed/35399956
http://dx.doi.org/10.3389/fendo.2022.849204

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