Suppression of non‐small‐cell lung cancer A549 tumor growth by an mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐triphenylphosphonium and a senolytic drug

Certain somatic mutations in mtDNA were associated with tumor progression and frequently found in a homoplasmic state. We recently reported that pyrrole‐imidazole polyamide conjugated with the mitochondria‐delivering moiety triphenylphosphonium (PIP‐TPP) targeting an mtDNA mutation efficiently induc...

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Detalles Bibliográficos
Autores principales: Tsuji, Kohei, Kida, Yuki, Koshikawa, Nobuko, Yamamoto, Seigi, Shinozaki, Yoshinao, Watanabe, Takayoshi, Lin, Jason, Nagase, Hiroki, Takenaga, Keizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990788/
https://www.ncbi.nlm.nih.gov/pubmed/35112436
http://dx.doi.org/10.1111/cas.15290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990788/
https://www.ncbi.nlm.nih.gov/pubmed/35112436
http://dx.doi.org/10.1111/cas.15290

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