Benzylic Dehydroxylation of Echinocandin Antifungal Drugs Restores Efficacy against Resistance Conferred by Mutated Glucan Synthase

[Image: see text] Each year, infections caused by fungal pathogens claim the lives of about 1.6 million people and affect the health of over a billion people worldwide. Among the most recently developed antifungal drugs are the echinocandins, which noncompetitively inhibit β-glucan synthase, a membr...

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Detalles Bibliográficos
Autores principales: Logviniuk, Dana, Jaber, Qais Z., Dobrovetsky, Roman, Kozer, Noga, Ksiezopolska, Ewa, Gabaldón, Toni, Carmeli, Shmuel, Fridman, Micha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991007/
https://www.ncbi.nlm.nih.gov/pubmed/35347986
http://dx.doi.org/10.1021/jacs.2c00269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991007/
https://www.ncbi.nlm.nih.gov/pubmed/35347986
http://dx.doi.org/10.1021/jacs.2c00269

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