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Promiscuity mapping of the S100 protein family using a high-throughput holdup assay

S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca(2+)-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies. There are about 20 distinct human S100 proteins with numerous po...

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Detalles Bibliográficos
Autores principales: Simon, Márton A., Bartus, Éva, Mag, Beáta, Boros, Eszter, Roszjár, Lea, Gógl, Gergő, Travé, Gilles, Martinek, Tamás A., Nyitray, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991199/
https://www.ncbi.nlm.nih.gov/pubmed/35393447
http://dx.doi.org/10.1038/s41598-022-09574-2