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Loss of β4-spectrin impairs Na(v) channel clustering at the heminode and temporal fidelity of presynaptic spikes in developing auditory brain
Beta-4 (β4)-spectrin, encoded by the gene Sptbn4, is a cytoskeleton protein found at nodes and the axon initial segments (AIS). Sptbn4 mutations are associated with myopathy, neuropathy, and auditory deficits in humans. Related to auditory dysfunction, however, the expression and roles of β4-spectri...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991253/ https://www.ncbi.nlm.nih.gov/pubmed/35393465 http://dx.doi.org/10.1038/s41598-022-09856-9 |